Hereditary coproporphyria (HCP) and Variegate porphyria (VP) have skin manifestations and acute attacks.

In variegate porphyria, there is increased production of protoporphyrinogens due to a mutation in protoporphyrinogen oxidase in the haem synthesis pathway. Urinary porphobilinogen is usually normal, unlike acute intermittent porphyria. Variegate porphyria is associated with intermittent abdominal pain, mood disturbances, and a bullous eruption that occurs over sun-exposed areas.