Mitral valve prolapse is associated with a risk of endocarditis, atrial septal defect and the long QT syndrome. Squatting increases afterload and this leads to an increase in the intensity of the murmur.

Mitral valve prolapse is commonly found in patients with Marfan syndrome, Ehlers- Danlos syndrome, and adult polycystic kidney disease, and occasionally hypertrophic cardiomyopathy