Testicular feminisation is a cause of primary amenorrhoea rather than secondary amenorrhoea. Androgen insensitivity syndrome (AIS), formerly known as testicular feminization, is an X-linked recessive condition resulting in a failure of normal masculinization of the external genitalia in chromosomally male individuals.

Most patients with complete androgen insensitivity have a female gender. Some patients are first seen in the teenage years for evaluation of primary amenorrhea, but most are identified in the newborn period by the presence of inguinal masses, which later are identified as testes during surgery.