Immunosuppresants: Corticosteroids act
on cytosolic rather
than cell membrane receptors. Both
mycophenolate and azathioprine
Approximately 1 in 300 Caucasians have thiopurine methyl transferase (TPMT)
deficiency. TPMT is the enzyme that metabolises 6-mercaptopurine and its deficiency results in high risk of azathioprine toxicity.
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