Methotrexate: Binding of methotrexate to dihydrofolate reductase reduces nucleotide synthesis as well
as amino acids serine and methionine. Folinic acid rescue is usually
given after methotrexate therapy
(e.g. 24 hours) to reduce myelosuppression side effects.
Methotrexate is
associated with interstitial pneumonitis. This is rare but a serious complication. Chest radiography reveals a
diffuse interstitial or mixed
interstitial and alveolar infiltrate, with a predilection for the lower lung
fields.
Common side effects of gold are mouth
ulceration, leucopenia, proteinuria and skin rashes.
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