Friday 2 March 2018



Brugada Syndrome is an autosomal dominant disease with variable expression. In approximately 20% of cases, the underlying cause of Brugada syndrome is a genetic defect in the SCN5A gene, which encodes the sodium channel.
Brugada Syndrome manifests with syncope and cardiac arrest, typically occurring in the third and fourth decade of life. The syndrome is characterised by a typical electrocardiogram (ECG) pattern of ST segment elevation in leads V1 to V3, and incomplete or complete right bundle branch block. ICD is indicated in patients with symptoms suggestive of, or evidence of arrhythmias.

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