Chylomicrons are triglyceride-rich lipoproteins (75%-95% of their core lipid is triglyceride) made in the small intestine from ApoB-48 (apoliproprotein). VLDL are made in the liver from ApoB-100.

Ventricular septal defect (VSD) is the commonest form of congenital heart disease. Maladie de Roger is a loud systolic murmur despite a small VSD. Antibiotic prophylaxis should be used at all times. The systolic murmur does become softer as right heart pressures increase and a right to left shunt may develop in Eisenmenger's syndrome (leading to cyanosis).